The work presented is aimed at the investigation of the influence of beam-to-column connection typologies on the seismic response of MR-Frames designed according to the Theory of Plastic Mechanism Control (TPMC). The investigated typologies are four partial strength connections designed in order to obtain the same flexural resistance. The first three joints are partial-strength semi-rigid connections while the fourth one is a beam-to-column connection equipped with friction pads properly designed to assure the earthquake input energy dissipation. Beam-to-column joints are modelled by means of rotational inelastic spring elements located at the ends of the beams whose moment-rotation curve is characterized by a cyclic behaviour accounting for stiffness and strength degradation and pinching phenomenon. The parameters characterizing the joints cyclic hysteretic behaviour have been calibrated on the base of experimental results aiming to the best fitting. The prediction of the structural response has been carried out by means of IDA analyses.