SUMMARY: Seismic reliability of steel structures isolated using the frictional pendulum system bearings and subjected to artificial earthquake ground motions is studied herein. The superstructure is idealised as a linear shear-type flexible building as well as the FPS devices are described by adopting a widespread model which considers the variation of the friction coefficient with the velocity. The uncertainty affecting both the seismic inputs, modelled as non stationary random processes within the power spectral density method, and the friction coefficient at large velocity is considered through appropriate probability density functions. Incremental dynamic analyses are developed in order to evaluate the fragility curves related to both superstructure and isolation level. Finally, considering the seismic hazard curve related to a site near Sant’Angelo dei Lombardi (Italy), the seismic reliability of the overall steel system is evaluated.